Embolizing agent and kit for blood vessel Embolization
No dosage restrictions and no catheter adhesion
Overview
Vascular embolization treatment, a minimally invasive surgery for
various blood vessel‐related conditions, has emerged as a crucial
method in treating such as hemorrhage, arteriovenous malformation,
aneurysms, and hypervascular tumors. Liquid agents present unique
advantages, penetrating distal peripheral vasculature inaccessible to
solid counterparts while allowing modulation of penetration depth through
compositional adjustments. Conventionally used liquid embolic
substances include N-butyl cyanoacrylate (NBCA) and ethylene vinyl
alcohol copolymer (Onyx ). NBCA embolizes blood vessels by
polymerization reaction with blood, and Onyx embolizes blood vessels
by precipitation and aggregation in blood. However, in NBCA and Onyx ,
there is a problem that the embolic substances may stick to the tip of the
catheter, injure the inner wall of the blood vessel and the catheter
insertion site, and cause bleeding.
According to the present invention, it is possible to provide an embolic
agent and a kit for blood vessel embolization comprising the embolic
agent and the embolic agent having excellent injectability with a syringe
and safety and stability in vivo while having blood vessel embolization
properties equivalent to those of conventional embolic agents. The
present invention comprises as an active ingredient a copolymer of a
monomer containing a cationic functional group and a monomer
containing an aromatic group, wherein at least a part of the copolymer
has a structure represented by general formula.
Concentration of embolic substance ≥ 30 mg/mL & stable blood gel formed 1 min after addition without adhesion to catheter
Product Application
・Intravascular embolic substances for cerebral intravascular
・Surgical hemostatic agents, adhesives
・Wound dressing agent for skin defect
Related Works
[1] Z.Jin et al., PNAS 2022 Vol.119 No.42 e2206685119.
IP Data
IP No. ： WO2023/163170
Inventor ： Hailong FAN,OSANAI Toshiya, Zhiping JIN, KUROKAWA Takayuki, NONOYAMA Takayuki
keyword ： Material, Medical／Welfare device