Risk Marker for Diabetic Kidney Disease

Phenyl Sulfate can be a predictor for a risk of developing Diabetic Kidney Disease

Summary

Diabetic kidney disease(DKD) occurs in approximately 20-30% of all diabetic subjects. It is difficult to identify type 2 diabetes patients who are at risk of developing progressive DKD based only measurements of glomerular filtration rate (GFR) and albuminuria. In this study, from animal experiments and the U-CARE cohort study, inventors showed that phenyl sulfate(PS) could be a predictor and a risk factor for developing progressive DKD.

Effect of PS on kidney tissue in db/db mice

Clinical significance of PS in DKD patients (U-CARE cohort study)

A schematic model of the generation and toxicity of PS

IP Data

IP No.　 ： WO2017/564968(National Phase：JP, US, EP, CN, TW)
Inventor ： ABE Takaaki, OGAWA Shin, TOMIOKA Yoshihisa
keyword ： Others