Cargo-specific degraders using selective autophagy

Degradation and clearance of disease related intracellular targets by autophagy

Introduction

　Autophagy is a intracellular degradation mechanism and is related to a large scale of diseases, e.g. neurodegenerative disease, cancer and metabolic disease. It is a promising approach in drug discovery. 　By now, current technologies cannot selectively trigger autophagy targeting specific proteins. This invention established a system to introduce autophagy embracing the target of interest (See the figure below).
　PROTAC, a targeted protein degradation technology, is existent but it is a ubiquitin-proteasome system, thus the scope of targeted proteins are limited to soluble intracellular ones. Meanwhile, this invention’s system is suitable for aggregated proteins, organelles and pathogens, etc.

This invention: AUTACs (Autophagy-targeting chimeras)

Degradation of fragmented mitochondria by autophagy

IP Data

IP No.　 ： PCT/JP2018/3576 (T16-040),PCT/JP2018/25941 (T16-123)
Inventor ： ARIMOTO Hirokazu, ITTO Kaori, TAKAHASHI Daiki
keyword ： Medical drug(including research tools)