Lymphatic drug delivery system
Administration of little amount of prepared liquid drug shows excellent antitumor efficacy!
Overview
Many cancers spread to regional lymph nodes
through the lymphatic vessels. Intravenous
administration of chemotherapeutic agents through
blood vessels is a common treatment for metastatic
lymph nodes. Drugs administered intravenously leak
from the capillaries into the interstitium in peripheral
tissues and are reabsorbed by the blood vessels and
lymphatic vessels. However, the lymphatic system is
characterized by the preferential uptake of large-sized
particles and polymers, and thus anticancer drugs,
which are generally small molecules, are considered
difficult to deliver to the lymphatic system.
A modern drug delivery system by lymphatic vessels
can deliver drugs to a target lymph nodes directly. In
this way, not only these lymph nodes, but also the
downstream lymphatic system can be treated properly.
This invention shows that a liquid preparation having
a particular osmotic pressure range provided high drug
retention in the target lymph node, high delivery to the
downstream lymph node, and excellent drug efficacy.
The investigation for diseases other than cancers
is being researched with data unpublished.
Anticancer effect by lymphatic drug delivery system
IP Data
IP No. ： Publication No. WO2019/45005
Inventor ： KODAMA Tetsuya, MORI shiro
keyword ： Medical drug(including research tools)