Intracellular delivery vehicle

Cationic Polymers without cell toxicity

Overview

　Cationic polymers are known to be used as nucleic drug delivery carrier because they are ease to be introduced into cells. However, it has been reported that the cationic polymers may inhibit cell proliferation by unspecific binding to intracellular proteins. This invention provides cationic polymer nanoparticles (nanogels) for intracellular delivery without inhibiting cell proliferation, by conducting radical polymerization reaction using a cationic polymerization initiator ADIP.　

Properties of NIPAM-based cationic nanogels synthesizing through ADIP:
・Can be delivered into many kinds of cells (e.g. HeLa) simply by mixing cells and the nanogels without special treatment
・In cells, nanogels do not effect the cell division or the differentiation of the brown adipocyte
・Intracellular temperature can be measured because of the heat-sensitive unit NIPAM

Cell toxicity (Left) Intracellular temperature(Right)

Product Application

・Drug Delivery Vehicles
・Cell Incubation Indicators
・Cell Thermometers

IP Data

IP No.　 ： WO2017/043484　
Inventor ： TOKUYAMA Hidetoshi, OKANO Kentaro et. al.
keyword ： nanogel, nanoparticle, polymerization, DDS