New method for screening mitochondrial function-enhancer

Drug-screening method based on new regulatory mechanism of mitochondria & the products

Abstract

CNS degenerative disorders, including AD and PD, are increasingly believed to be caused due to mitochondrial disability leading to neuronal death. This inventor recently identified a novel intracellular regulatory factor XXX in the CNS neurons that contributes to mitochondrial homeostasis, and the inventor further developed a method for screening beneficial ability of chemicals to enhance mitochondrial function due to elevation of the XXX level.

Effect

✓Increasing XXX level by neuron-specific gene transfer of YYY, a component of XXX, facilitated neuronal viability and mRNA expression of a mitochondrial key enzyme, COXI(cytochrome c oxidase subunit I), and elevated neuronal ATP production as well.
✓ Molecules A, B, C, and D showed all the ability to elevate COXI mRNA level and ATP content via increased endogenous XXX level.
✓ Inventor has a anti-YYY antibody beneficial for this drug-screening

IP Data

IP No.　 ： JP2018-058171
Inventor ： YAMAKUNI Toru
keyword ： Medical drug(including research tools), Agriculture, Food item