Compounds that suppress ferroptosis

Vitamin K and its derivative

Overview

　Ferroptosis is a form of regulated cell death associated with neurodegenerative diseases (e.g. Alzheimer's disease) and organ damage and is attracting attention as a therapeutic target. In this study, we found that vitamin K (especially the reduced form), a functional food ingredient, has a potent preventing effect on ferroptosis. Although a higher intake of vitamin K than those from the diet would be required to exert the anti-ferroptotic effect, vitamin K can be safely used even at high doses due to the no harmful effect reported. Thus, high-dose vitamin K supplementation is expected to be commercialized as a dietary supplement, functional food, and medicine.

Features・Outstandings

Product Application

・Medicine　
・Functional Foods

Related Works

[1] https://doi.org/10.1038/s41586-022-05022-3 Mishima et al. Nature 608 778–783(2022)

IP Data

IP No.　 ： WO2022/075444
Inventor ： Eikan Mishima, Kiyotaka Nakagawa, Shunya Ito
keyword ： Medical drug(including research tools)