Inhibitor of bone resorption

To prevent and control of the progression of bone resorption with food

Overview

　Rheumatoid arthritis and periodontal disease are known to cause bone resorption due to inflammation. Although various drugs have been administered, it is desirable to inhibit and prevent bone resorption through food intake, which is easier and more convenient.　
　In this invention, we found that two-step fermented rice bran (FRB) inhibits the formation of osteoclasts caused by inflammation and suppresses bone resorption. Furthermore, the mechanism of the suppression was confirmed, and the route to directly and indirectly suppress the formation of osteoclasts was elucidated.

Bone resorption experiments in the mouse calvaria

Product Application

・Food with functional claims and food for specified health uses　
・Pharmaceutical composition for prevention and treatment of bone resorption due to inflammation

Publication

[1] Noguchi T, Kitaura H, et al., Nutrients. 2023, 15(13):3044.

IP Data

IP No.　 ： JP2023-071905
Inventor ： SHIRAKAWA Hitoshi, KITAURA Hideki, NOGUCHI Takahiro, OSAKI Yusuke, MIZOGUCHI Itaru
keyword ： food for health,suppliment,bone resorption, rheumatoid arthritis, periodontal disease